Anti-IL22RA1 (Interleukin-22 Receptor Subunit alpha-1, IL-22 Receptor Subunit alpha-1, IL-22R-alpha-

The interleukin-22 receptor A1 (IL-22 Ra1), also known as CRF2-9, is a 557aa, ~65kD type I transmembrane protein of the type II cytokine receptor family (CRF). IL-22 RA1 forms an IL-22 signaling complex with IL-10 RB/CRF2-4 on epithelial and stromal cells. IL-22 engagement of the signaling complex stimulates antimicrobial, acute phase and proinflammatory protein expression. IL-22 Ra1 also pairs with IL-20 RB to form a receptor that is responsive to IL-20 and IL-24. Within the 211aa extracellular domain, mouse IL-22 Ra1 shares 78% and 94% aa sequence identity with human and rat IL-22 RA1, respectively. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10ul to label 1-2.5x10e5 cells, Optimal dilutions to be determined by the researcher. Absorption: 482nm and 564nm , Emission: 675nm, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PerCP conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.