Anti-IL-22 (Detector), clone 4E6

Interleukin-22 (Il-22),also known as Il-10-related T cell-derived inducible factor (Il-TIF) was initially identified as a gene induced by Il-9 in mouse T cells and mast cells. Mouse Il-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with human Il-22 and Il-10,respectively. The mouse Il-22 gene is localized to chromosome 10. Although it exists as a single copy gene in many mouse strains,the Il-22 gene is duplicated in some mouse strains including C57B1/6,FVB and 129. The two mouse genes designated Il-TIF alpha and Il-TIF beta,share greater than 98% sequence homology in their coding region. Il-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. Il-22 is produced by normal mouse T cells upon Con A activation. Mouse Il-22 expression is also induced in various organs upon lipopolysaccharide injection,suggesting that Il-22 may be involved in inflammatory responses. The functional Il-22 receptor complex consists of two receptor subunits,Il-22 R (previously an orphan receptor named CRF2-9) and Il-10 R beta (previously known as CRF2-4),belonging to the class II cytokine receptor family. Protein function: Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:17204547). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:17204547). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB (PubMed:10875937, PubMed:18599299). Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways (PubMed:25793261, PubMed:31311100). Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN. Promotes epithelial cell spreading. [The UniProt Consortium]