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![Anti-IL-2 (swine), Biotin conjugated](https://www.biomol.com/media/image/07/0b/3b/KPB1964S-050_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
KPB1964S-050 | 50 µg | - | - |
3 - 8 business days* |
535.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Cytokine produced by activated CD4-positive helper T-cells and to a lesser... more
Product information "Anti-IL-2 (swine), Biotin conjugated"
Protein function: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high- affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells. [The UniProt Consortium]
Keywords: | Anti-IL2, Anti-IL-2, Anti-TCGF, Anti-Interleukin-2, Anti-T-cell growth factor |
Supplier: | Kingfisher Biotech |
Supplier-Nr: | KPB1964S |
Properties
Application: | ELISA |
Conjugate: | Biotin |
Host: | Rabbit |
Species reactivity: | swine |
Immunogen: | Recombinant Swine IL-2 |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K05429 | Matching products |
UniProt ID : | P26891 | Matching products |
Gene ID | GeneID 396868 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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