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![Anti-IKK gamma, clone 55AT986.5.78](https://www.biomol.com/media/image/b1/f5/19/NSJ-F40422-0-08ML_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F40422-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F40422-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes the regulatory subunit of the... more
Product information "Anti-IKK gamma, clone 55AT986.5.78"
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. Protein function: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response, this function requires 'Lys-27'-linked polyubiquitination. [The UniProt Consortium]
Keywords: | Anti-IKKG, Anti-FIP3, Anti-NEMO, Anti-FIP-3, Anti-IKBKG, Anti-IKKAP1, Anti-IKK-gamma, Anti-IkB kinase subunit gamma, Anti-NF-kappa-B essential modifier, Anti-I-kappa-B kinase subunit gamma, Anti-NF-kappa-B essential modulator, IKK gamma Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F40422 |
Properties
Application: | WB, ELISA |
Antibody Type: | Monoclonal |
Clone: | 55AT986.5.78 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | This IKK gamma antibody was raised using purified His-tagged recombinant full length human IKKg. |
Format: | Purified |
Database Information
KEGG ID : | K07210 | Matching products |
UniProt ID : | Q9Y6K9 | Matching products |
Gene ID | GeneID 8517 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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