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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F50935-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F50935-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form... more
Product information "Anti-IkB alpha"
In 1X PBS, pH 7.4, with 0.09% sodium azide. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine). Protein function: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. [The UniProt Consortium]
Keywords: | Anti-IKBA, Anti-NFKBIA, Anti-IkB-alpha, Anti-IkappaBalpha, Anti-I-kappa-B-alpha, Anti-NF-kappa-B inhibitor alpha, Anti-Major histocompatibility complex enhancer-binding protein MAD3, IkB alpha Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F50935 |
Properties
Application: | WB, IHC, FC, IF, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A portion of amino acids 12-41 from the human protein was used as the immunogen for this IkB alpha antibody. |
Format: | Purified |
Database Information
KEGG ID : | K04734 | Matching products |
UniProt ID : | P25963 | Matching products |
Gene ID | GeneID 4792 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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