Anti-IFNAR1 Rabbit Monoclonal Antibody (Clone 110)

alpha/beta receptor 1 (IFNAR1), also known as type I IFN receptor 1, is a class II helical cytokine receptor involved in the antiviral response. It is composed of an extracellular domain, which contains four fibronectin type III subdomains, a transmembrane domain, and an intracellular domain, which contains a tyrosine kinase 2 (TYK2) phosphorylation site, and forms a heterodimer with IFNAR2. It is ubiquitously expressed and binds to type I IFNs, including IFN-alpha, IFN-beta, and IFN-omega, which, upon binding, together with IFNAR2 signals through JAK1, TYK2, and various STATs. Knockout of Ifnar1 sensitizes fibroblasts to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vitro and has commonly been used as an immunosuppressive model to study viral infections in vivo. SNPs in IFNAR1 are associated with increased risk of viral infections, lung cancer, multiple sclerosis, and cerebral malaria, as well as adverse reactions to vaccinations. Cayman's IFNAR1 Rabbit Monoclonal Antibody (Clone 110) can be used for immunocytochemistry (ICC) and immunofluorescence (IF) applications.Synonyms: Interferon Alpha/Beta Receptor 1, Interferon alpha/beta Receptor 1, CRF2-1, CRF2 member 1, Cytokine Receptor Class-II Member 1, Cytokine Receptor Family 2 Member 1, Type I IFN Receptor 1, Type I Interferon Receptor 1. Immunogen: Recombinant mouse IFNAR1. Clone Designation: 110. Formulation: (Request formulation change), 50 or 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: 0.2 µm filtered solution in PBS. Host: Rabbit. Isotype: IgG. Applications: ICC, IF. Cross Reactivity: (+) Ifnar1.