Anti-IDO1, clone 10.1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG23317.50	50 µg		-	-	6 - 14 business days*		712.00€

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Protein function: Catalyzes the first and rate limiting step of the catabolism of the essential... more

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Product information "Anti-IDO1, clone 10.1"

Protein function: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). [The UniProt Consortium]

Keywords:	Anti-IDO, Anti-IDO1, Anti-IDO-1, Anti-Indoleamine 2,3-dioxygenase 1, Anti-Indoleamine-pyrrole 2,3-dioxygenase
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG23317

Properties

Application:	IHC (frozen), WB
Antibody Type:	Monoclonal
Clone:	10.1
Conjugate:	No
Host:	Mouse
Species reactivity:	human, mouse
Immunogen:	GST-fused synthetic peptide around aa. 78-184 of Human IDO1
MW:	45 kD
Format:	Purified