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![Anti-human PECAM-1](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-10-3539-100 | 100 µg | - |
3 - 11 business days* |
2,558.00€
|
|||
ABE-10-3539-500 | 500 µg | - |
3 - 11 business days* |
2,558.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This monoclonal antibody binds to human PECAM-1 (platelet endothelial cell adhesion molecule-1,... more
Product information "Anti-human PECAM-1"
This monoclonal antibody binds to human PECAM-1 (platelet endothelial cell adhesion molecule-1, CD31) a specific component of endothelial cell junctions. PECAM-1 is also expressed in platelets and leukocytes. Protein function: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells, PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock- induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis. [The UniProt Consortium]
Keywords: | Anti-CD31, Anti-PECA1, Anti-GPIIA', Anti-PECAM1, Anti-PECAM-1, Anti-EndoCAM, Anti-Platelet endothelial cell adhesion molecule, Monoclonal Antibody to human PECAM-1 |
Supplier: | Abeomics |
Supplier-Nr: | 10-3539 |
Properties
Application: | IP |
Antibody Type: | Monoclonal |
Clone: | BV8 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Database Information
KEGG ID : | K06471 | Matching products |
UniProt ID : | P16284 | Matching products |
Gene ID | GeneID 5175 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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