Anti-human CD43, clone HI161, PE/XFD700, XFD700 Same Structure to Alexa Fluor(TM) 700*

Anti-human CD43, clone HI161, PE/XFD700, XFD700 Same Structure to Alexa Fluor(TM) 700*
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABD-104311P0 25 tests - -

3 - 8 business days*

351.00€
ABD-104311P1 100 tests - -

3 - 8 business days*

978.00€
ABD-104311P2 500 tests - -

3 - 8 business days*

3,310.00€
 
The HI161 monoclonal antibody reacts with human CD43, a 95 - 135 kD transmembrane protein... more
Product information "Anti-human CD43, clone HI161, PE/XFD700, XFD700 Same Structure to Alexa Fluor(TM) 700*"
The HI161 monoclonal antibody reacts with human CD43, a 95 - 135 kD transmembrane protein commonly located on the surface of plasma cells, thymocytes, neutrophils, myelomas and T cells. In some organisms, CD43 plays a role in the downregulation of cell adhesion, promotes tumor necrosis factor biosynthetic process and acts to negatively regulate T cell proliferation. From a research standpoint, it is of biological interest due to its association with vital macromolecules/ligands such as EZR. CD43 is a fairly uncommon antibody target, with a little more than 5000 publications in the last decade. Even still, CD43 has been widely used in immunology research, frequently serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography. Protein function: Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E- selectin. Acts as a T-cell counter-receptor for SIGLEC1. [The UniProt Consortium] This antibody was purified through affinity chromatography and conjugated to PE/XFD700 (ex/em = 566/721 nm). XFD700 is manufactured by AAT Bioquest, and it has the same chemical structure of Alexa Fluor(R) 700 (Alexa Fluor(R) is the trademark of ThermoFisher). It is compatible with the 561 nm laser and 697/58 nm bandpass filter (for example, as in the BD FACSMelody(TM)).
Keywords: Anti-SPN, Anti-CD43, Anti-GPL115, Anti-GALGP, Anti-Sialophorin, Anti-Leukocyte Sialoglycoprotein, Anti-Leukosialin, Anti-Galactoglycoprotein, PE/XFD700 Anti-human CD43 Antibody *HI161, XFD700 Same Structure to Alexa Fluor(TM) 700*
Supplier: AAT Bioquest
Supplier-Nr: 104311P

Properties

Application: FC, ELISA, IHC, WB
Antibody Type: Monoclonal
Clone: HI161
Conjugate: PE/XFD700
Host: Mouse
Species reactivity: human
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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