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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
MM-0061-P | 50 µg | - | - |
3 - 8 business days* |
488.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Involved in intracellular signal transduction mediated by cytokines and growth... more
Product information "Anti-Hrs, clone 19-5"
Protein function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. [The UniProt Consortium]
Keywords: | Anti-Hrs, Anti-HRS, Anti-HGS, Anti-Protein pp110, Anti-Hepatocyte growth factor-regulated tyrosine kinase substrate |
Supplier: | MediMabs |
Supplier-Nr: | MM-0061-P |
Properties
Application: | WB, IHC, IP |
Antibody Type: | Monoclonal |
Clone: | 19-5 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, rat, mouse, monkey |
Format: | Purified |
Database Information
KEGG ID : | K12182 | Matching products |
UniProt ID : | O14964 | Matching products |
Gene ID : | GeneID 9146 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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