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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1267-0.1 | 100 µg | - |
3 - 11 business days* |
639.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Non-classical major histocompatibility class Ib molecule involved in immune... more
Product information "Anti-HLA-E Monoclonal Antibody (Clone:MEM-E/06)"
Protein function: Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1- KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334). [The UniProt Consortium]
Keywords: | , Anti-HLA-E Monoclonal Antibody (Clone:MEM-E/06) |
Supplier: | Abeomics |
Supplier-Nr: | 30-1267 |
Properties
Application: | FC, IP, IHC |
Antibody Type: | Monoclonal |
Clone: | MEM-E/06 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, non-human primates |
Immunogen: | Bacterially expressed recombinant HLA-E refolded with beta2-microglobulin and peptide. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06751 | Matching products |
UniProt ID : | P13747 | Matching products |
Gene ID : | GeneID 3133 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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