Anti-HLA-DRA (HLA Class II Histocompatibility Antigen, DR alpha Chain, MHC Class II Antigen DRA, HLA

HLA-DR is a transmembrane human major histocompatibility complex 2 (MHC II) family member, which consists of a 34kD (alpha) subunit and one of several 28kD (beta) subunits. HLA-DR is expressed primarily by B cells and dendritic cells (DC), where it binds peptides derived from internalized and processed antigenic proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD4T cells. This interaction is central to antigen specificity in the adaptive immune response. HLA-DR alleles, polymorphisms, and aberrant expression are linked to a variety of diseases including autoimmunity and cancer. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Hybridoma: Fusion of a mouse myeloma with B cells obtained from a mouse immunized with HLA-DR expressing RPMI8866 cells. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4°C. Freezing PerCP conjugates will result in a substantial loss of activity. PerCP conjugates are sensitive to light.