Anti-HLA-DR (Clone L243)

HLA-DR is a MHC Class II cell surface receptor heterodimer composed of a 33-35 kDa alpha chain, a ~30 kDa beta chain, and a 10-30 amino acid ligand. When the heterodimer is fully combined on the cell surface of an antigen-presenting cell, such as macrophages, B cells, and dendritic cells, they present that ligand primarily to CD-4+ T cells. This presentation coupled with the T cell response can stimulate or suppress an antibody response to that ligand. HLR-DRs have been linked to a number of autoimmune disorders such as rheumatoid arthritis, lupus, and psoriasis as well as diabetes, hepatitis, and sclerosis among a number of others. Cayman's HLA-DR Monoclonal Antibody (Clone L243) detects HLA-DR with or without attached ligand. The predicated size of the HLA-DRalpha or HLA-DRbeta subunits is ~29-30 kDa.Synonyms: HLA Class II Histocompatibility Antigen DR, MHC Class II Antigen DR. Immunogen: Human lymphoblastoid cell line (RPMI 8866). Clone Designation: L243. Formulation: (Request formulation change), 100 µg of protein G-purified IgG. Storage Buffer: PBS, pH 7.2, containing 50% glycerol, with 0.1% BSA, and 0.02% sodium azide. Host: Mouse. Isotype: IgG2a. Applications: FC, ICC, IF, IHC, IP, and WB.