Anti-HLA-DMB (MHC class II antigen DMB, Really interesting new gene 7 protein)

HLA-DMB(major histocompatibility complex, class II, DM beta), also known as D6S221E, RING7,, HLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein that in humans is , encoded by the HLA-DMB gene. The HLA-DMB gene is mapped on 6p21.32. HLA-DMB belongs to the , HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) , and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays , a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class , II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are , expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains , 6 exons. HLA-DMA and -DMB appear to encode subunits of a functional heterodimer that is critical in , the pathway of class II antigen presentation. UniProt Number: P28068, Gene ID: HLA-DMB, Applications: Suitable for use in Western Blot and Immunohistochemistry (Paraffin). Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.