Anti-HIF1-alpha (IHC)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IHC-00460-T	10 µl (2 µg)		-		2 - 8 business days*		178.00€
IHC-00460	100 µl (20 µg)		-		2 - 8 business days*		668.00€

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Protein function: Functions as a master transcriptional regulator of the adaptive response to... more

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Product information "Anti-HIF1-alpha (IHC)"

Protein function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. [The UniProt Consortium]

Keywords:	Anti-HIF1A, Anti-bHLHe78, Anti-BHLHE78, Anti-HIF1-alpha, Anti-HIF-1-alpha, Anti-Member of PAS protein 1, Anti-ARNT-interacting protein, Anti-PAS domain-containing protein 8, Anti-Hypoxia-inducible factor 1-alpha
Supplier:	Bethyl Laboratories
Supplier-Nr:	IHC-00460

Properties

Application:	IHC, ICC-IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: rat, zebrafish, chicken, turkey, goat, bovine, dog, horse, rabbit, guinea pig, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, grass carp, northern pike, atlantic cod, duckbill platypus, gansu zokor)
Immunogen:	synthetic peptide. The epitope recognized by IHC-00460 maps to a region between residues 775 and the C-terminus (residue 826) of human hypoxia-inducible factor 1, alpha subunit using the numbering given in Swiss-Prot entry Q16665 (GeneID 3091).
Format:	Antigen Affinity Purified