Anti-HIF-1alpha (C-Term)

Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1alpha migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival. HIF-1alpha is an endothelial PAS domain protein 1 (EPAS-1) family member with phosphorylation dependent activities. Cayman Chemical's HIF-1alpha polyclonal antibody can be used for WB analysis for HIF-1alpha on samples from human, mouse, and simian. It is not suitable for ICC or IP. Other applications for use of this antibody have not yet been tested.Synonyms: ARNT-interacting Protein, Hypoxia-Inducible Factor 1alpha. Immunogen: Peptide from the C-terminal region of human HIF-1alpha. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: IHC and WB. UniProt Accession #: Q16665. Origin: Animal/Rabbit.