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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
200-301-GS5 | 100 µg | - | - |
6 - 10 business days* |
698.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This protein A purified mouse monoclonal antibody reacts specifically with human HbS beta sickle... more
Product information "Anti-Hemoglobin beta S, clone 23E5.H6.G6.C1.H7.F7.G9.F6"
This protein A purified mouse monoclonal antibody reacts specifically with human HbS beta sickle isoform. Anti-HbS is purified from tissue culture supernatant by protein A purification. This antibody does not react with the HbA, HbF, HbC, or HbA-2 isoform. HbS antibodies detect the E6V mutant in the hemoglobin beta subunit. Functional adult hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (alpha2beta2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA2. Hemoglobin S is the predominant hemoglobin in people with sickle cell disease. The alpha chain is normal. The disease-producing mutation exists in the beta chain, giving the molecule the structure, alpha2betaS2. People who have one sickle mutant gene and one normal beta gene have sickle cell trait which is benign. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Perhaps the most significant mutation is the E6V in the beta subunit and the cause of SCD, but other relevant isoforms of Hb are observed. HbS antibody does not react to other forms of Hb. This antibody is ideal for investigators involved in Cardiovascular and developmental biology research.
Keywords: | Anti-HBB E6V |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 200-301-GS5 |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Clone: | 23E5.H6.G6.C1.H7.F7 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | synthetic peptide corresponding to amino acid residues near the N-terminus of Hb beta-subunit conjugated to KLH. |
Format: | Liquid |
Database Information
KEGG ID : | K13823 | Matching products |
UniProt ID : | P68871 | Matching products |
Gene ID : | GeneID 3043 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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