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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V7367IHC-7ML | 7 ml | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-H7-B4 / VTCN1, clone B7H4/2652R"
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer. Protein function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. [The UniProt Consortium]
Keywords: | Anti-B7h.5, Anti-B7-H4, Anti-B7 homolog 4, Anti-Protein B7S1, Anti-T-cell costimulatory molecule B7x, Anti-Immune costimulatory protein B7-H4, Anti-V-set domain-containing T-cell activation inhibitor 1, H7-B4 Antibody / VTCN1 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V7367IHC |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | B7H4/2652R |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A recombinant human partial protein |
Format: | Purified |
Database Information
KEGG ID : | K06747 | Matching products |
UniProt ID : | Q7Z7D3 | Matching products |
Gene ID | GeneID 79679 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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