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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-AMAb91226.25 | 25 µl | - |
7 - 10 business days* |
335.00€
|
|||
ATA-AMAb91226.100 | 100 µl | - |
7 - 10 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Transcription factor playing an important role in primary neurulation and in... more
Product information "Anti-GRHL2, clone CL3760"
Protein function: Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456). Binds directly to the consensus DNA sequence 5'- AACCGGTT-3' acting as an activator and repressor on distinct target genes. During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up- regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions. Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair. In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation. In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293). [The UniProt Consortium] Validated by orthogonal and standard strategies. Buffer: The antibodies are delivered in 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 87% and to rat: 87%. Epitope specificity: VVKAEDFTPV.
Keywords: | Anti-BOM, Anti-GRHL2, Anti-Brother of mammalian grainyhead, Anti-Transcription factor CP2-like 3, Anti-Grainyhead-like protein 2 homolog |
Supplier: | Atlas Antibodies |
Supplier-Nr: | AMAb91226 |
Properties
Application: | IHC, ICC |
Antibody Type: | Monoclonal |
Clone: | CL3760 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: NRVQVLKTVP VNLSLNQDHL ENSKREQYSI SFPESSAIIP VSGITVVKAE DFTPVFMAPP VHYPRGDGEE QRVVIFEQTQ YDVPSLATHS AYLKDDQRST PDSTYSESFK DAATEKFRSA SVGAEEYMYD QTSSGTFQYT LEATKSLRQK (ATA-APrEST86696) |
Database Information
KEGG ID : | K09275 | Matching products |
UniProt ID : | Q6ISB3 | Matching products |
Gene ID : | GeneID 79977 | Matching products |
Protein Atlas Nr. : | ENSG00000083307 |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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