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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the... more
Product information "Anti-GNE"
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. Protein function: Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. [The UniProt Consortium]
Keywords: | Anti-GNE, Anti-GLCNE, EC=2.7.1.60, Anti-ManAc kinase, EC=3.2.1.183, Anti-UDP-GlcNAc-2-epimerase, Anti-N-acetylmannosamine kinase, Anti-UDP-GlcNAc-2-epimerase/ManAc kinase, Anti-UDP-N-acetylglucosamine 2-epimerase (hydrolyzing), GNE Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-63016 |
Properties
Application: | WB, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant protein of human GNE |
Database Information
KEGG ID : | K12409 | Matching products |
UniProt ID : | Q9Y223 | Matching products |
Gene ID : | GeneID 10020 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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