Anti-GluR1, clone RH95

Anti-GluR1 Monoclonal Antibody is directed against rat GluR1 protein. The antibody was Protein G purified. Reactivity is expected against mouse and human. Cross reactivity with GluR1 from other species has not been determined. Protein function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. [The UniProt Consortium]