Anti-Geminin / GMNN, clone GMNN/3665

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
NSJ-V8963-20UG	20 µg		-	-	3 - 10 business days*		361.00€
NSJ-V8963-100UG	100 µg		-	-	3 - 10 business days*		781.00€

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0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Geminin is a nuclear... more

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Product information "Anti-Geminin / GMNN, clone GMNN/3665"

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Geminin is a nuclear protein that regulates the initiation of DNA replication during the cell cycle. Protein function: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:9635433, PubMed:14993212, PubMed:20129055, PubMed:24064211). It is degraded during the mitotic phase of the cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Its destruction at the metaphase- anaphase transition permits replication in the succeeding cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). [The UniProt Consortium]

Keywords:	Anti-GMNN, Anti-Geminin, Geminin Antibody / GMNN
Supplier:	NSJ Bioreagents
Supplier-Nr:	V8963

Properties

Application:	IF, IHC (paraffin)
Antibody Type:	Monoclonal
Clone:	GMNN/3665
Conjugate:	No
Host:	Mouse
Species reactivity:	human
Immunogen:	A recombinant protein fragment
Format:	Apoptosis, Cell Cycle, DNA Repair