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![Anti-GAPDH, clone RM114](https://www.biomol.com/media/image/95/5f/g0/NSJ-R20198-0-1ML_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R20198-0.1ML | 100 µl | - | - |
3 - 10 business days* |
737.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This recombinant GAPDH antibody... more
Product information "Anti-GAPDH, clone RM114"
Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This recombinant GAPDH antibody reacts to Glyceraldehyde 3-phosphate dehydrogenase. Protein function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:3170585, PubMed:11724794). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D- glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:3170585, PubMed:11724794). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1- dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. [The UniProt Consortium]
Keywords: | Anti-GAPDH, Anti-CDABP0047, Anti-Peptidyl-cysteine S-nitrosylase GAPDH, Anti-Glyceraldehyde-3-phosphate dehydrogenase, GAPDH Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R20198 |
Properties
Application: | WB, IP, ICC, IHC, ChIP |
Antibody Type: | Monoclonal |
Clone: | RM114 |
Conjugate: | No |
Host: | Rabbit |
Immunogen: | A peptide corresponding to the C-terminus of GAPDH |
Format: | Purified |
Database Information
KEGG ID : | K00134 | Matching products |
UniProt ID : | P04406 | Matching products |
Gene ID | GeneID 2597 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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