Anti-GABRB3

Anti-GABRB3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-90038.60 60 µl -

7 - 16 business days*

198.00€
E-AB-90038.120 120 µl -

7 - 16 business days*

317.00€
E-AB-90038.200 200 µl -

7 - 16 business days*

525.00€
 
This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one... more
Product information "Anti-GABRB3"
This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. Protein function: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception. [The UniProt Consortium]
Keywords: GABRB3, GABA(A) receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit beta-3, GABRB3 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-90038

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant fusion protein of human GABRB3

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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