Anti-FLT1(icrucumab biosimilar) mAb

Item number Size Datasheet Manual SDS Delivery time Quantity Price
DIM-BME100131.50 50 µg - -

7 - 16 business days*

115.00€
DIM-BME100131.100 100 µg - -

7 - 16 business days*

227.00€
 
Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB... more
Product information "Anti-FLT1(icrucumab biosimilar) mAb"
Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (Ref.11). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). [The UniProt Consortium]
Keywords: Anti-FLT, Anti-FLT-1, Anti-VEGFR-1, Anti-VEGFR1, Anti-FLT1(icrucumab biosimilar) mAb
Supplier: DIMA
Supplier-Nr: BME100131

Properties

Antibody Type: Monoclonal
Conjugate: No
Host: Human
Species reactivity: human
Format: Lyophilized

Database Information

CAS : 12| Matching products
UniProt ID : P17948 | Matching products

Handling & Safety

Storage: -20°C (avoid repeat freezing and thawing cycles)
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-FLT1(icrucumab biosimilar) mAb"
Write a review
or to review a product.
Viewed