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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG55584.100 | 100 µl | - | - |
6 - 14 business days* |
584.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and... more
Product information "Anti-FLT-4 / VEGFR3"
Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr- 185', and of AKT1 at 'Ser-473'. [The UniProt Consortium]
Keywords: | Anti-FLT4, Anti-FLT-4, Anti-VEGFR3, Anti-VEGFR-3, EC=2.7.10.1, Anti-Fms-like tyrosine kinase 4, Anti-Tyrosine-protein kinase receptor FLT4, Anti-Vascular endothelial growth factor receptor 3 |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG55584 |
Properties
Application: | FC, WB |
Antibody Type: | Monoclonal |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Purified His-tagged Human FLT-4 / VEGFR3 protein |
Format: | Purified |
Database Information
KEGG ID : | K05097 | Matching products |
UniProt ID : | P35916 | Matching products |
Gene ID | GeneID 2324 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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