Anti-Fibrinogen (alpha chain)

Fibrinogen is a hexameric glycoprotein that has roles in coagulation and hemostasis. It is comprised of two sets of Aalpha, Bbeta, and gamma polypeptide chains encoded by FGA, FGB, and FGG, respectively, in humans. Fibrinogen is synthesized in hepatocytes and secreted into the plasma. Following thrombin-mediated cleavage of N-terminal fibrinopeptides from the Aalpha and Bbeta chains, yielding the alpha and beta chains, respectively, fibrinogen assembles into fibrin protofibrils and then mature fibers, which provide structure and viscoelasticity to blood clots. Mutations in FGA, FGB, or FGG have been found in patients with afibrinogenemia or hypofibrinogenemia. Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disease. Immune complexes containing citrullinated fibrinogen have been found in patients with anti-citrullinated protein antibody-positive rheumatoid arthritis. Cayman's Fibrinogen (alpha chain) Polyclonal Antibody can be used for Western blot applications. The antibody recognizes the alpha chain of fibrinogen at 70 kDa from human samples.Synonyms: FGA. Immunogen: Peptide from the C-terminal region of human fibrinogen (alpha chain). MW: 70 kDa. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2 with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: WB. Cross Reactivity: (+) Fibrinogen (alpha chain), (-) Fibrinogen (beta chain), (-) Fibrinogen (gamma chain). UniProt Accession #: P02671.