Anti-FFAR4 (GPR120) (C-Term)

G Protein-Coupled Receptor (GPR120) is a GPCR activated by the presence of long chain free fatty acids and is expressed in adipocytes and pro-inflammatory macrophages. The activation of GPR120 results in elevated Ca2+ and activation of the ERK cascade. omega-3 Fatty acid constituents such as DHA and EPA mediate GPR120 signaling resulting in inhibition of TLR and TNF-alpha inflammatory signaling pathways in a beta-arrestin2/TAB1 dependent manner. The anti-inflammatory effects of GPR120 are indirectly involved in promoting insulin secretion and free fatty acid-induced inhibition of apoptosis. The predicted size for GPR120 is 42.2 kDa and the observed detection is approximately 43 kDa by Western blot.Synonyms: Free Fatty Acid Receptor 4, GPCR129, G Protein-Coupled Receptor 120, GT01, O3FAR1, PGR4. Immunogen: Synthetic peptide from the C-terminal region of human FFAR4. Formulation: (Request formulation change), Peptide affinity-purified polyclonal antibody. Storage Buffer: TBS, pH 7.4 when reconstituted in 500 µl deionized water. Host: Rabbit. Applications: ELISA, ICC, IHC, and WB. UniProt Accession #: Q5NUL3.