Anti-FFAR1

Polyclonal Antibody against Human FFAR1, Gene description: free fatty acid receptor 1, Alternative Gene Names: FFA1R, GPR40, Validated applications: ICC, Uniprot ID: O14842, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis, receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. [The UniProt Consortium] Mouse gene identity: 86% Rat gene identity: 86%