Anti-FCRL5 (Fc Receptor-like Protein 5, FcR-like Protein 5, BXMAS1-like Protein 2, mBXMH2, Fc Recept

Fc Receptor-Like 5 (FCRL5), also known as FcRH3 (FcRH5 in human), IRTA2, and CD307e, is a 90-95kD member of the FCRL family of proteins whose aa sequence is reminiscent of classical Fc receptors. FCLR molecules are type I transmembrane proteins that contain from three to nine Immunoglobulin-like domains. They are differentially expressed within the B cell lineage, and can either promote or inhibit B cell proliferation and activation. Mature mouse FCRL5 consists of a 470aa extracellular domain (ECD), a 21aa transmembrane segment, and a 79aa cytoplasmic region. FCRL5 expression is restricted to mature B lineage cells in lymphoid tissues and blood, and is particularly noted to be expressed on T-independent marginal zone and B1 B cells. Its ligation inhibits signaling through the B cell antigen receptor. Epstein-Barr virus transformation of B cells induces the up-regulation of surface FCRL5 by a direct effect of its EBNA2 protein on FCRL5 gene transcription. FCRL5 on B cells functions as a receptor for the orthopoxvirus MHC class I-like protein OMCP. Based on the literature and testing, both mouse and human FCRL5 will bind to purified IgG with high affinity. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 10ul labels up to 1x10e6 cells, Optimal dilutions to be determined by the researcher. Absorption: 620-650nm , Emission: 660-670nm, Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. For maximum recovery of product, centrifuge the original vial prior to removing the cap.