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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA038546.25 | 25 µl | - |
7 - 10 business days* |
335.00€
|
|||
ATA-HPA038546.100 | 100 µl | - |
7 - 10 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Adapter protein that plays a role in endocytosis via clathrin-coated pits.... more
Product information "Anti-FCHSD2"
Protein function: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to- late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 97% and to rat: 98%
Keywords: | Anti-NWK1, Anti-Carom, Anti-FCHSD2, Anti-KIAA0769, Anti-Protein nervous wreck 1, Anti-SH3 multiple domains protein 3, Anti-F-BAR and double SH3 domains protein 2 |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA038546 |
Properties
Application: | ICC, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN DLECHGAAVS EQSRA (ATA-APrEST80579) |
Database Information
KEGG ID : | K20125 | Matching products |
UniProt ID : | O94868 | Matching products |
Gene ID : | GeneID 9873 | Matching products |
Protein Atlas Nr. : | ENSG00000137478 |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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