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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA026872.25 | 25 µl | - |
7 - 10 business days* |
335.00€
|
|||
ATA-HPA026872.100 | 100 µl | - |
7 - 10 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Adapter protein containing an immunoreceptor tyrosine-based activation motif... more
Product information "Anti-FCER1G"
Protein function: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'- dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen- specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 85% and to rat: 88%
Keywords: | Anti-FCER1G, Anti-FcRgamma, Anti-FceRI gamma, Anti-Fc-epsilon RI-gamma, Anti-Fc receptor gamma-chain, Anti-IgE Fc receptor subunit gamma, Anti-High affinity immunoglobulin epsilon receptor subunit gamma |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA026872 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: KIQVRKAAIT SYEKSDGVYT GLSTRNQETY ETLKHEKPPQ (ATA-APrEST72093) |
Database Information
KEGG ID : | K07983 | Matching products |
UniProt ID : | P30273 | Matching products |
Gene ID : | GeneID 2207 | Matching products |
Protein Atlas Nr. : | ENSG00000158869 |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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