Anti-Fatty Acid Desaturase 1 (Clone 3A10.1)

Fatty acid desaturase 1 (FADS1), also known as Delta5 desaturase, is a 444-amino acid transmembrane protein encoded by FADS1. It catalyzes conversion of dihomo-gamma-linolenic acid (Cay-90230) to arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) and omega-3 arachidonic acid (Cay-90011) to eicosapentaenoic acid (Cay-90110, Cay-90110.1, Cay-21908) during the production of omega-6 and omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), respectively. Hepatic FADS1 protein levels and mRNA expression are increased in mice with high-fat diet-induced obesity and non-alcoholic steatohepatitis (NASH). Tissue-selective knockdown of Fads1 in the liver, adipose tissue, and reticuloendothelial system of adult hyperlipidemic LDL receptor-null mice promotes hepatic inflammation and formation of atherosclerotic plaques and suppresses hepatic lipogenesis. Increased expression of FADS1 positively correlates with disease-free survival and overall survival times in patients with esophageal squamous cell carcinoma (ESCC). Cayman's Fatty Acid Desaturase 1 Monoclonal Antibody (Clone 3A10.1) can be used for immunoprecipitation (IP), ELISA, and Western blot (WB) applications. The antibody recognizes FADS1 at approximately 45 kDa from human samples.Synonyms: Acyl-CoA (8-3)-Desaturase, FADS1, Delta5 Fatty Acid Desaturase. Immunogen: Recombinant human FADS1 protein. Clone Designation: 3A10.1. Formulation: (Request formulation change), 300 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA and WB. Cross Reactivity: (+) FADS1, (-) FADS2. UniProt Accession #: O60427.