Anti-FAM38A/PIEZO1

Anti-FAM38A/PIEZO1
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-CAB23380.20 20 µl - -

9 - 20 business days*

149.00€
G-CAB23380.100 100 µl - -

9 - 20 business days*

566.00€
 
Protein function: Pore-forming subunit of a mechanosensitive non-specific cation channel... more
Product information "Anti-FAM38A/PIEZO1"
Protein function: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678, PubMed:25955826). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R- Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). [The UniProt Consortium]
Keywords: Anti-Mib, Anti-FAM38A, Anti-Protein FAM38A, Anti-Membrane protein induced by beta-amyloid treatment, Anti-Piezo-type mechanosensitive ion channel component 1, FAM38A/PIEZO1 Monoclonal Antibody
Supplier: Assay Genie
Supplier-Nr: CAB23380

Properties

Application: ELISA, WB, IHC-P
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human

Database Information

UniProt ID : Q92508 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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