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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V7090IHC-7ML | 7 ml | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. Early... more
Product information "Anti-EMI-1, clone FBXP5"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. Protein function: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. [The UniProt Consortium]
Keywords: | Anti-EMI1, Anti-FBXO5, Anti-F-box only protein 5, Anti-Early mitotic inhibitor 1, EMI-1 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V7090IHC |
Properties
Application: | IHC |
Antibody Type: | Monoclonal |
Clone: | FBXP5 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A human partial recombinant N-terminal protein fragment was used as the immunogen for the EMI-1 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K10292 | Matching products |
UniProt ID : | Q9UKT4 | Matching products |
Gene ID : | GeneID 26271 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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