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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ7226 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Eukaryotic translation initiation factor 3... more
Product information "Anti-EIF3A / Eukaryotic translation initiation factor 3 subunit A"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation, formation of cytoplasmic translation initiation complex, and viral translational termination-reinitiation. Located in cytosol, nucleolus, and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. Protein function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem- loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). [The UniProt Consortium]
Keywords: | Anti-eIF3a, Anti-eIF3 p167, Anti-eIF3 p185, Anti-eIF3 p180, Anti-eIF-3-theta, Anti-Eukaryotic translation initiation factor 3 subunit A, Anti-Eukaryotic translation initiation factor 3 subunit 10, EIF3A Antibody / Eukaryotic translation initiation factor |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ7226 |
Properties
Application: | WB, IHC (paraffin), FC, Direct ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant human protein (amino acids K13-H477) |
Format: | Purified |
Database Information
KEGG ID : | K03254 | Matching products |
UniProt ID : | Q14152 | Matching products |
Gene ID : | GeneID 8661 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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