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![Anti-DYRK2 (Dual-specificity Tyrosine-phosphorylation Regulated Kinase 2)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
D9904-07C.100 | 100 µg | - | - |
3 - 19 business days* |
901.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DYRK2 (Dual-specificity tyrosine [Y] phosphorylation regulated kinase 2) is a 58-62kD member of... more
Product information "Anti-DYRK2 (Dual-specificity Tyrosine-phosphorylation Regulated Kinase 2)"
DYRK2 (Dual-specificity tyrosine [Y] phosphorylation regulated kinase 2) is a 58-62kD member of the MNB/DYRK subfamily, CMGC Ser/Thr protein kinase family of enzymes. It is expressed in testis and shows dual substrate specificity, autophosphorylation on Tyr382 to self-activate, and a Ser/Thr phosphorylation of target molecules. Substrates include NFATc, glycogen synthase, and p53. p53 phosphorylation on Ser46 initiates cell apoptosis. Human DYRK2 is 601aa in length. It contains one kinase catalytic domain (aa222-535). One isoform variant shows an alternate start site at Met74. This shorter isoform was used for immunization. Thus, over aa1-107 (or aa74 - 180 of the long form), human DYRK2 shares 93% aa identity with mouse DYRK. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml , Immunohistochemistry: 25ug/ml , Optimal dilutions to be determined by the researcher. Hybridoma: Myeloma cells with B cells from Balb/c mice. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | EC=2.7.12.1, Anti-Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
Supplier: | United States Biological |
Supplier-Nr: | D9904-07C |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | 11D89 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant corresponding to aa1-107 in human DYRK2 expressed in E. coli (NP_003574). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K18669 | Matching products |
UniProt ID : | Q92630 | Matching products |
Gene ID | GeneID 8445 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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