Anti-DUP / CDT1

Anti-DUP / CDT1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ7296 100 µg - -

3 - 10 business days*

772.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CDT1 (Chromatin licensing and DNA... more
Product information "Anti-DUP / CDT1"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CDT1 (Chromatin licensing and DNA replication factor 1), also called DUP (Double parked homolog) is a protein that in humans is encoded by the CDT1 gene. The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. Protein function: Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre- replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene. [The UniProt Consortium]
Keywords: Anti-DUP, Anti-Double parked homolog, Anti-DNA replication factor Cdt1, DUP Antibody / CDT1
Supplier: NSJ Bioreagents
Supplier-Nr: RQ7296

Properties

Application: WB, Direct ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: recombinant human protein (amino acids R19-L357)
Format: Apoptosis, Cell Cycle, DNA Repair

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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