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![Anti-DR5 (Death Receptor 5, CD262, HGNC:11905, KILLER, TNF-related Apoptosis-inducing Ligand Recepto](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
D9300-52B.100 | 100 µg | - | - |
3 - 19 business days* |
716.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Apoptosis in mammalian cells can be initiated through two major interrelated pathways, one... more
Product information "Anti-DR5 (Death Receptor 5, CD262, HGNC:11905, KILLER, TNF-related Apoptosis-inducing Ligand Recepto"
Apoptosis in mammalian cells can be initiated through two major interrelated pathways, one involving engagement of the TNF family of death receptors, the other involving the release of cytochrome c from mitochondria. Unlike other members of the TNF ligand family, TNF-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in tumor cell lines, but not in normal cells, suggesting that TRAIL could potentially represent a powerful cancer therapeutic. Recent experiments have revealed that one of the key regulators of TRAIL expression in lymphocytes is the NF-kappa B transcription factors. Several TRAIL receptors have been identified: two of these receptors TRAIL-R1:DR4 and TRAIL-R2:DR5 contain cytoplasmic death domains and signal apoptosis, while two other decoy receptors, TRAIL-R3:DcR1 and TRAIL-R4:DcR2 lack a functional death domain and do not mediate apoptosis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-TRAIL receptor 2, Anti-Death receptor 5, Anti-TNF-related apoptosis-inducing ligand receptor 2, Anti-Tumor necrosis factor receptor superfamily member 10B |
Supplier: | United States Biological |
Supplier-Nr: | D9300-52B |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide corresponding to aa280-296 [EHLLEPAEAERSQRRRL] of human TRAIL-R2/DR5. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04722 | Matching products |
UniProt ID : | O14763 | Matching products |
Gene ID | GeneID 8795 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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