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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
T8181-11C.100 | 100 µg | - | - |
3 - 19 business days* |
901.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human TRAIL R2, is a type 1 membrane protein of the TNF R family, designated TNFRSF10B, which is... more
Product information "Anti-DR5 (Apo2, Trail-R2, TRAIL Receptor2, Trick2, Killer, Death Receptor5, CD262, KILLER, KILLER/DR"
Human TRAIL R2, is a type 1 membrane protein of the TNF R family, designated TNFRSF10B, which is a receptor for TRAIL (APO2 ligand). The human TRAIL R2 cDNA encodes a 440aa precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Among TNF receptor family proteins, TRAIL R2 is most closely related to TRAIL R1/DR4, sharing 55aa sequence identity. Binding of trimeric TRAIL to TRAIL R2 induces apoptosis. The induction of apoptosis likely requires oligomerization of the receptor. The human TRAIL R2/Fc chimera neutralizes the ability of TRAIL to induce apoptosis. Besides TRAIL R2, an additional TRAIL R1/DR4, which tranduces apoptosis signaling, and two TRAIL decoy receptors, which antagonize TRAIL-induced apoptosis, have been reported. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-TRAIL-R2, Anti-Death receptor 5, Anti-TRAIL receptor 2, Anti-TNF-related apoptosis-inducing ligand receptor 2, Anti-Tumor necrosis factor receptor superfamily member 10B |
Supplier: | United States Biological |
Supplier-Nr: | T8181-11C |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 11n198 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant corresponding to aa56-128 from human TRAIL R2 expressed in E. coli (NP_003833). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04722 | Matching products |
UniProt ID : | O14763 | Matching products |
Gene ID | GeneID 8795 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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