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This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. Protein function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. [The UniProt Consortium]
Keywords:
Anti-LIG1, Anti-DNA ligase 1, Anti-DNA ligase I, Anti-Polydeoxyribonucleotide synthase [ATP] 1, DNA Ligase1 Polyclonal Antibody
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