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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES10269.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES10269.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of... more
Product information "Anti-DGLA"
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010], Protein function: Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2- arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:26668358, PubMed:23502535). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Cell membrane , Multi-pass membrane protein . Cell junction, synapse, postsynaptic density membrane , Multi-pass membrane protein . Early endosome membrane , Multi-pass membrane protein . Cell projection, dendritic spine membrane , Multi-pass membrane protein . Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner. .
Keywords: | Anti-DAGLA, Anti-C11orf11, Anti-DGL-alpha, Anti-DAGL-alpha, Anti-Diacylglycerol lipase-alpha, Anti-Sn1-specific diacylglycerol lipase alpha, Anti-Neural stem cell-derived dendrite regulator, DGLA rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES10269 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse |
Immunogen: | Synthesized peptide derived from human protein . at AA range: 900-980 |
MW: | 114 kD |
Format: | Purified |
Database Information
KEGG ID : | K13806 | Matching products |
UniProt ID : | Q9Y4D2 | Matching products |
Gene ID : | GeneID 747 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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