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![Anti-DARPP-32](https://www.biomol.com/media/image/02/7d/b2/Cay29259-100_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay29259-100 | 100 µl | - |
6 - 10 business days* |
564.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Dopamine and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32) is a member of... more
Product information "Anti-DARPP-32"
Dopamine and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32) is a member of the protein phosphatase inhibitor 1 family and is encoded by the PPP1R1B gene in humans. It is primarily expressed in medium spiny neurons of dopamine-innervated brain regions and is localized to the cytoplasm. DARPP-32 contains multiple phosphorylation sites that allow it to function as a central regulator and integrator of signaling cascades induced by a variety of neurotransmitters, neuropeptides, and psychostimulatory agents. It also contains a protein phosphatase 1 (PP1) binding domain. DARPP-32 inhibits PP1 when phosphorylated at threonine 34 (Thr34) by PKA and inhibits PKA when phosphorylated at Thr75 by cyclin-dependent kinase 5 (Cdk5). Ppp1r1b-/- mice have decreased amphetamine-induced GABA and dopamine release in the striatum and are less susceptible to catalepsy induced by raclopride (Cay-17422) compared to wild-type mice. Increased DARPP-32 protein levels have been identified in breast, prostate, gastric, and colon cancer tumors. DARPP-32 levels are also increased in postmortem-derived dorsolateral prefrontal cortex from individuals with schizophrenia or bipolar disorder. Cayman's DARPP-32 Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes DARPP-32 at ~32 kDa from mouse and rat samples.Synonyms: Protein Phosphatase 1 Regulatory Subunit 1B. Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of rat DARPP-32 conjugated to KLH. Formulation: (Request formulation change), 100 µl of polyclonal antibody prepared from pooled rabbit serum via chromatography on an affinity column prepared with the N-terminal peptide used as antigen. Storage Buffer: 10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol. Host: Rabbit. Applications: IHC, WB.
Keywords: | Protein Phosphatase 1 Regulatory Subunit 1B |
Supplier: | Cayman Chemical |
Supplier-Nr: | 29259 |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse, rat |
Immunogen: | Peptide corresponding to amino acid residues from the N-terminal region of rat DARPP-32 conjugated to KLH |
Format: | Affinity Purified |
Database Information
KEGG ID : | K15494 | Matching products |
UniProt ID : | Q6J4I0 | Matching products |
Gene ID | GeneID 360616 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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