Anti-Cytokeratin FITC (Clone C-11)

Cytokeratins (CKs) are intermediate filaments proteins and members of the cytokeratin protein family. The cytokeratin family is composed of at least 20 unique gene products, which fall into two categories: type I acidic cytokeratins, CK9-CK20, and type II neutral-basic cytokeratins, CK1-CK8. Each cytokeratin is composed of a central rod containing four alpha-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. Cytokeratins are major structural proteins expressed in epithelial cells and localized to the cytoplasm where they form heterozygous type I-type II pairs. They primarily function to protect epithelial cells from mechanical and non-mechanical stresses that induce cell rupture and death. Cytokeratins have additional isoform- and tissue-specific functions, including the modulation of protein synthesis and cell size during epithelial growth and roles in skin pigmentation. Cayman's Cytokeratin Monoclonal FITC Antibody (Clone C-11) can be used for flow cytometry (FC) and immunofluorescence (IF) applications. This antibody recognizes cytokeratins 4, 5, 6, 8, 10, 13, and 18 from human samples.Synonyms: CKs, Keratin, pan-Cytokeratin. Clone Designation: C-11. Formulation: (Request formulation change), 100 µg of protein A-purified, fluorescein-labeled monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Applications: FC, IF. Cross Reactivity: (+) Cytokeratins 4, (+) Cytokeratins 5, (+) Cytokeratins 6, (+) Cytokeratins 8, (+) Cytokeratins 10, (+) Cytokeratins 13, (+) Cytokeratins 18. Origin: Animal/Mouse.