Anti-CYP2R1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA042949.25	25 µl		-		7 - 10 business days*		358.00€
ATA-HPA042949.100	100 µl		-		7 - 10 business days*		477.00€

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Protein function: A cytochrome P450 monooxygenase involved in activation of vitamin D precursors.... more

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Product information "Anti-CYP2R1"

Protein function: A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol) (PubMed:12867411, PubMed:15465040, PubMed:18511070). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives (PubMed:15465040, PubMed:18511070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR, NADPH-ferrihemoprotein reductase) (PubMed:12867411, PubMed:15465040, PubMed:18511070). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 93% and to rat: 92%

Keywords:	Anti-CYP2R1, Anti-Cytochrome P450 2R1, Anti-Vitamin D 25-hydroxylase
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA042949

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: TYEDTDFQHM IELFSENVEL AASASVFLYN AFPWIGILPF GKHQQLFRNA AVVYDFLSRL IEKASVNRKP QLPQHFVDAY LDEMDQGKND PSSTFSKENL IFSVGELIIA GTETTTNVLR (ATA-APrEST72366)