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Promotion:
Save 30% on all primary antibodies by Arigo Biolaboratories!
*1
*1 Offer expires 16/12/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ARG42091.50 | 50 µg | - | - |
6 - 14 business days* |
30 %
|
520.00€
364.00€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and... more
Product information "Anti-CYP24A1"
Protein function: A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:24893882, PubMed:15574355, PubMed:8679605, PubMed:11012668, PubMed:16617161). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:24893882, PubMed:15574355). With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product (PubMed:11012668, PubMed:8679605). Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S- hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:8679605). [The UniProt Consortium]
Keywords: | Anti-CYP24, Anti-24-OHase, Anti-Cytochrome P450-CC24, Anti-Cytochrome P450 24A1, Anti-Vitamin D(3) 24-hydroxylase, Anti-1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG42091 |
Properties
Application: | IHC (paraffin), WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Goat |
Species reactivity: | human (Expected: rat) |
Immunogen: | Synthetic peptide around the internal region of Human CYP24A1. (C-RKYDIQATDN) (NP_000773.2, NP_001122387.1) |
MW: | 59 kD |
Format: | Ammonium Sulfate Precipitated |
Database Information
KEGG ID : | K07436 | Matching products |
UniProt ID : | Q07973 | Matching products |
Gene ID : | GeneID 1591 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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