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Promotion:
Save 30% on all primary antibodies by Arigo Biolaboratories!
*1
*1 Offer expires 16/12/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ARG40642.100 | 100 µl | - | - |
6 - 14 business days* |
30 %
|
624.00€
436.80€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and... more
Product information "Anti-Cyclin D1"
Protein function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. [The UniProt Consortium]
Keywords: | Anti-BCL1, Anti-CCND1, Anti-BCL-1, Anti-BCL-1 oncogene, Anti-PRAD1 oncogene, Anti-G1/S-specific cyclin-D1, Anti-B-cell lymphoma 1 protein |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG40642 |
Properties
Application: | ICC, IF, IHC (paraffin), IP, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthetic peptide derived from Human Cyclin D1 |
MW: | 33 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04503 | Matching products |
UniProt ID : | P24385 | Matching products |
Gene ID : | GeneID 595 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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