Anti-CXCR1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Chemokine CXC Motif Receptor 1, also known as IL8R, is the receptor for IL8. Morris et al.(1992) mapped the gene to chromosome 2q35. Hartl et al.(2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Binding of IL-8 to its receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. CXCR1 binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Protein function: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor (PubMed:1840701). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G- protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). [The UniProt Consortium]