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Promotion:
Save 30% on all primary antibodies by Arigo Biolaboratories!
*1
*1 Offer expires 16/12/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ARG56613.50 | 50 µg | - | - |
6 - 14 business days* |
30 %
|
520.00€
364.00€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils.... more
Product information "Anti-Cxcl12 / SDF-1"
Protein function: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. [The UniProt Consortium]
Keywords: | Anti-TLSF, Anti-PBSF, Anti-Sdf1, Anti-TPAR1, Anti-SDF-1, Anti-Cxcl12, Anti-C-X-C motif chemokine 12, Anti-Stromal cell-derived factor 1, Anti-Pre-B cell growth-stimulating factor, Anti-Thymic lymphoma cell-stimulating factor |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG56613 |
Properties
Application: | ELISA, WB, Neutr. |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Goat |
Species reactivity: | mouse |
Immunogen: | E.coli derived Recombinant Mouse SDF-1alpha (CXCL12).(KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK) |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K10031 | Matching products |
UniProt ID : | P40224 | Matching products |
Gene ID : | GeneID 20315 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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