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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C2099-68W1.100 | 100 µg | - | - |
3 - 19 business days* |
629.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CNOT4 is a 575aa protein with E3 ubiquitin ligase activity, mainly involved in protein... more
Product information "Anti-CNOT4 (CCR4-NOT Transcription Complex Subunit 4, CCR4-associated Factor 4, E3 Ubiquitin-protein"
CNOT4 is a 575aa protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal. Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.05-0.1ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Human skeletal muscle lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | EC=6.3.2.-, Anti-CCR4-associated factor 4, Anti-E3 ubiquitin-protein ligase CNOT4, Anti-CCR4-NOT transcription complex subunit 4, Anti-Potential transcriptional repressor NOT4Hp |
Supplier: | United States Biological |
Supplier-Nr: | C2099-68W1 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | bovine, chicken, human, mouse, rat, xenopus |
Immunogen: | Synthetic peptide corresponding to aa50-100 of human CNOT4. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K10643 | Matching products |
UniProt ID : | O95628 | Matching products |
Gene ID : | GeneID 4850 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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